%0 Journal Article
%T Engaging with Raman Spectroscopy to Investigate Antibody Aggregation
%A Ilokugbe Ettah
%A Lorna Ashton
%J -
%D 2018
%R https://doi.org/10.3390/antib7030024
%X Abstract In the last decade, a number of studies have successfully demonstrated Raman spectroscopy as an emerging analytical technique for monitoring antibody aggregation, especially in the context of drug development and formulation. Raman spectroscopy is a robust method for investigating protein conformational changes, even in highly concentrated antibody solutions. It is non-destructive, reproducible and can probe samples in an aqueous environment. In this review, we focus on the application and challenges associated with using Raman spectroscopy as a tool to study antibody aggregates. View Full-Tex
%K Raman spectroscopy
%K antibody
%K aggregation
%K protein structure
%U https://www.mdpi.com/2073-4468/7/3/24