%0 Journal Article
%T Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity
%A Joongkyu Park
%J -
%D 2018
%R https://doi.org/10.3390/proteomes6040040
%X Abstract Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity. View Full-Tex
%K phosphorylation
%K AMPA receptor complex
%K transmembrane AMPA receptor regulatory protein
%K synaptic plasticity
%U https://www.mdpi.com/2227-7382/6/4/40