%0 Journal Article
%T Overcoming the Blood每Brain Barrier. Challenges and Tricks for CNS Drug Delivery
%A Franciska Erdˋ
%A Luca Anna Bors
%J -
%D 2019
%R https://doi.org/10.3390/scipharm87010006
%X Abstract Treatment of certain central nervous system disorders, including different types of cerebral malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs due to possible serious side effects and/or lack of the brain penetration and, therefore, the efficacy of the drugs is diminished. During the last decade, several new technologies were developed to overcome barrier properties of cerebral capillaries. This review gives a short overview of the structural elements and anatomical features of the blood每brain barrier. The various in vitro (static and dynamic), in vivo (microdialysis), and in situ (brain perfusion) blood每brain barrier models are also presented. The drug formulations and administration options to deliver molecules effectively to the central nervous system (CNS) are presented. Nanocarriers, nanoparticles (lipid, polymeric, magnetic, gold, and carbon based nanoparticles, dendrimers, etc.), viral and peptid vectors and shuttles, sonoporation and microbubbles are briefly shown. The modulation of receptors and efflux transporters in the cell membrane can also be an effective approach to enhance brain exposure to therapeutic compounds. Intranasal administration is a noninvasive delivery route to bypass the blood每brain barrier, while direct brain administration is an invasive mode to target the brain region with therapeutic drug concentrations locally. Nowadays, both technological and mechanistic tools are available to assist in overcoming the blood每brain barrier. With these techniques more effective and even safer drugs can be developed for the treatment of devastating brain disorders. View Full-Tex
%K structure of the blood每brain barrier
%K models of the blood每brain barrier
%K drug delivery across the blood每brain barrier
%K nanocarriers
%K nanoparticles
%K vectors
%K intranasal delivery
%K efflux transporter inhibition
%K ultrasound-microbubbles
%U https://www.mdpi.com/2218-0532/87/1/6