%0 Journal Article
%T Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma
%A Amal M. El-Gayar
%A Mamdouh M. El-Shishtawy
%A Manal M. Nomir
%A Maryan W. Fahmi
%A Mohamed M. Salama
%J -
%D 2018
%R https://doi.org/10.3390/scipharm86040044
%X Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. In an attempt to understand some potential mechanisms of persistence and oncogenicity of Hepatitis C virus (HCV)-related HCC, microfibrillar-associated protein 4 (MFAP4), fibrotic indices and oxidative status biomarkers were assessed in the sera of 50 patients with HCV-associated HCC, 25 patients with HCV-related liver cirrhosis and 15 healthy individuals. Serum oxidized Coenzyme Q10 (CoQ10) and malondialdehyde showed significant elevation in HCC patients compared to the control group ( p < 0.001), as well as cirrhotic patients ( p < 0.05 and p < 0.001, respectively), while serum glutathione content and superoxide dismutase activity were significantly decreased in HCC patients compared to the control group ( p < 0.001). Serum MFAP4, aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4) and Forns index showed significant increase in HCC patients compared to the control group ( p < 0.001), while only APRI and FIB-4 were significantly different between HCC and cirrhotic patients ( p < 0.05), with a sensitivity of 86% and 92%, respectively, at cut off ¡Ý0.7 for APRI and ¡Ý1.57 for FIB-4. Therefore, increasing oxidative stress and fibrosis might mediate HCV induced cirrhosis and HCC. APRI and FIB-4 may be used as a simple non-expensive formula for the screening of HCC rather than MFAP4. View Full-Tex
%K HCC
%K MFAP4
%K fibrotic indices
%K oxidized Coenzyme Q10
%K oxidative status
%U https://www.mdpi.com/2218-0532/86/4/44