%0 Journal Article
%T Novel Direct Conversion of Microglia to Neurons
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2018.12.005
%X Direct cell reprogramming, the process by which a somatic cell is converted to another cell type, can potentially circumvent epigenetic changes and proliferative stages resulting from de-differentiation. Recently, Matsuda et al. (Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion; Neuronin in press) demonstrated that expression of transcription factor NeuroD1 can convert mouse microglia to neurons, both in vitro and in vivo
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30239-9