%0 Journal Article
%T Taking SCLC on a Bad LSD(1) Trip One NOTCH Further
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2019.02.009
%X Small cell lung cancer (SCLC) is an aggressive form of lung cancer for which therapeutic options are very limited. A new study (Augert et al. Sci. Signal. 2019;12:eaau2922) shows that inhibition of the LSD1 demethylase can induce derepression of NOTCH receptor genes and subsequent activation of the NOTCH pathway, potently suppressing the growth of SCLC
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30044-9