%0 Journal Article %T Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology %J - %D 2019 %R https://doi.org/10.1016/j.tins.2019.03.004 %X New animal/rodent data that utilize modern functional track tracing with optogenetics and designer receptors exclusively activated by designer drugs (DREADDS) technology show that the periaqueductal gray (PAG) is a rich substrate for the integration of active and passive responses to threat. Human data suggest that the PAG may be dysregulated in psychopathology that drives maladaptive behavior %U https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(19)30038-4