%0 Journal Article
%T Can Adding Constitutive Receptor Activity Redefine Biased Signaling Quantification?
%J -
%D 2019
%R https://doi.org/10.1016/j.tips.2019.01.002
%X Biased signaling, the differential activation of distinct signaling pathways, is currently at the center of pharmacology. Reliable characterization of biased ligands requires robust scales applicable to all ligand classes: agonists, neutral antagonists, and inverse agonists. To this end, constitutive receptor activity should be included in the models
%U https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(19)30002-1