%0 Journal Article
%T Unleashing the Power of ASH1L Methyltransferase
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2019.04.012
%X Trithorax histone methyltransferase Ash1/ASH1L is tightly regulated because it activates developmental gene transcription and counteracts Polycomb silencing. In this issue of Structure, Lee et al. (2019) Lee Y. Yoon E. Cho S. Schm£¿hling S. M¨¹ller J. Song J.-J. Structural basis of MRG15-mediated activation of the ASH1L histone methyltransferase by releasing an autoinhibitory loop. Structure. 2019; 27 ( this issue) : 846-852 Google Scholar and Hou et al. (2019) Hou P. Huang C. Liu C.-P. Yang N. Yu T. Yin Y. Zhu B. Xu R.-M. Structural insights into stimulation of Ash1L¡¯s H3K36 methyltransferase activity through Mrg15 binding. Structure. 2019; 27 ( this issue) : 837-845 Google Scholar report the crystal structure of ASH1L bound to its activator MRG15 and suggest a mechanism that releases ASH1L auto-inhibition
%U https://www.cell.com/structure/fulltext/S0969-2126(19)30134-0