%0 Journal Article
%T Glycogen Synthase Kinase-3¦Á Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
%J -
%D 2019
%R https://doi.org/10.1016/j.cmet.2019.01.005
%X £¿ Fatty acids upregulate GSK-3¦Á, which in turn phosphorylates PPAR¦Á at Ser280 £¿ Ser280 phosphorylation stimulates biased gene expression, favoring fatty acid uptake £¿ PPAR¦Á-Ser280 phosphorylation promotes the development of lipotoxic cardiomyopathy £¿ Fibrates inhibit Ser280 phosphorylation, thereby reversing cardiac lipotoxicit
%U https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30005-1