%0 Journal Article
%T Position Is Destiny: Metabolism and Cell Identity
%J -
%D 2019
%R https://doi.org/10.1016/j.cmet.2019.04.008
%X CTNNB1, encoding ¦Â-catenin, is frequently mutated in hepatocellular carcinoma, the most rapidly growing solid cancer in the US, and activating mutations in this gene are associated with increased expression of glutamine synthetase. A new report by Adebayo Michael et al. (2019) Adebayo Michael A.O. Ko S. Tao J. Moghe A. Yang H. Xu M. Russell J.O. Pradhan-Sundd T. Liu S. Singh S. et al. Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by beta-Catenin mutations. Cell Metab. 2019; 29 ( this issue) : 1135-1150 Google Scholar identifies mTOR as a direct target of WNT/¦Â-catenin signaling through increased production of glutamine, which is required for the carcinogenic effects of WNT/¦Â-catenin activity in the liver
%U https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30192-5