%0 Journal Article
%T Expanding the Role of STING in Cellular Homeostasis and Transformation
%J -
%D 2019
%R https://doi.org/10.1016/j.trecan.2019.02.001
%X The cytosolic DNA-sensing cGAS¨CSTING pathway was originally characterized as a key innate immune mediator responsible for the induction of antiviral genes in response to foreign DNA species in the cytosol. Mounting evidence, however, points to a complex role for cGAS and STING in cancer. Two recent reports, by Ranoa et al. ( Cancer Research, 2018;https://doi.org/10.1158/0008-5472.CAN-18-1972) and Nassour et al. ( Nature 2019;565:659¨C663), dissect the function of this pathway during the early steps of cellular transformation and shed light on the complexity and context-dependence of cGAS¨CSTING signaling in cancer
%U https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30017-2