%0 Journal Article
%T Mouse Models Shed Light on the SLIT/ROBO Pathway in Pancreatic Development and Cancer
%J -
%D 2019
%R https://doi.org/10.1016/j.trecan.2019.02.004
%X The SLIT/ROBO pathway is classically known for its role in axon guidance, and is frequently lost in pancreatic cancer, but the biology behind this is poorly understood. Two recent articles ( Nat. Commun. 2018;9:5082; Nat. Commun. 2018;9:5083) using mouse models show that SLIT/ROBO signaling is crucial to determine pancreatic cell identity during development and suppresses the stromal activation in disease, through divergent mechanisms. SLIT/ROBO proteins thus link development and cancer, but appear to have distinct functions in health and disease
%U https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30020-2