%0 Journal Article
%T Live or Let Die: T Cell Survival in Cancer Immunotherapy
%J -
%D 2019
%R https://doi.org/10.1016/j.immuni.2019.01.016
%X Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) Pai C.-C.S. Huang H.T. Lu X. Simons D.M. Park C. Chang A. Tamaki W. Liu W. Roybal K.T. Seagal J. et al. Clonal deletion of tumor-specific T cells by interferon-¦Ã confers therapeutic resistance to combination immune checkpoint blockade. Immunity. 2019; 50 ( this issue) : 477-492 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar show that, in the setting of low tumor burden, this combination regimen promotes interferon-¦Ã-dependent T cell hyperactivation and death and thus favors tumor progression
%U https://www.cell.com/immunity/fulltext/S1074-7613(19)30039-1