%0 Journal Article
%T DEL-1-Regulated Immune Plasticity and Inflammatory Disorders
%J -
%D 2019
%R https://doi.org/10.1016/j.molmed.2019.02.010
%X DEL-1 has recently emerged as a critical factor for homeostatic immunity by regulating diverse functions, ranging from stress myelopoiesis in the BM to initiation of local tissue inflammation and resolution thereof. In the BM, DEL-1 acts as a niche factor that promotes myelopoiesis; endothelial-cell derived DEL-1 regulates neutrophil recruitment to the inflamed tissue; and macrophage-derived DEL-1 regulates efferocytosis and the plastic reprogramming of macrophages to a proresolving phenotype with enhanced expression of anti-inflammatory and tissue-remodeling factors
%U https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(19)30045-0