%0 Journal Article
%T Metastasis Organotropism: Redefining the Congenial Soil
%J -
%D 2019
%R https://doi.org/10.1016/j.devcel.2019.04.012
%X Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as ˇ°organotropism.ˇ± Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism
%U https://www.cell.com/developmental-cell/fulltext/S1534-5807(19)30282-5