%0 Journal Article
%T Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2018.12.008
%X £¿ BRCA2-mutant cells rely on BER, ATR signaling, splicing, and MMEJ for survival £¿ APEX2 and FEN1 represent potential drug targets in BRCA-mutant tumors £¿ BRCA-mutant cells require the endonuclease function and PCNA association of APEX2 £¿ A cell-based reporter demonstrates that FEN1 participates in MME
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)31062-1