%0 Journal Article
%T Obstacles to Scanning by RNase E Govern Bacterial mRNA Lifetimes by Hindering Access to Distal Cleavage Sites
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.01.044
%X £¿ A monophosphorylated 5¡ä end stimulates mRNA degradation by the endonuclease RNase E £¿ Its ability to cut is hindered by obstacles between the 5¡ä end and cleavage sites £¿ Effective obstacles include bound ribosomes, proteins, and sRNAs £¿ RNase E appears to scan RNA linearly from the 5¡ä end along single-stranded region
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30064-4