%0 Journal Article
%T Venetolax with Azacitidine Drains Fuel from AML Stem Cells
%J -
%D 2019
%R https://doi.org/10.1016/j.stem.2018.12.005
%X In Nature Medicine, Pollyea et al. (2018) Pollyea D.A. Stevens B.M. Jones C.L. Winters A. Pei S. Minhajuddin M. DĄŻAlessandro A. Culp-Hill R. Riemondy K.A. Gillen A.E. et al. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia. Nat. Med. 2018; 24 : 1859-1866 Crossref PubMed Scopus (2) Google Scholar recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cycle, and depleted ATP in leukemia stem cells
%U https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30595-2