%0 Journal Article %T Gaining Weight: Insulin-Eating Islet Macrophages %J - %D 2019 %R https://doi.org/10.1016/j.immuni.2018.12.026 %X The role of the immune system in homeostasis of pancreatic ¦Â cells in type 2 diabetes mellitus is poorly characterized. In a recent issue of Cell Metabolism, Ying et al. (2018) Ying W. Lee Y.S. Dong Y. Seidman J.S. Yang M. Isaac R. Seo J.B. Yang B.-H. Wollam J. Riopel M. et al. Expansion of islet-resident macrophages leads to inflammation 1 affecting ¦Â cell proliferation and function in obesity. Cell Metabolism. 2018; ( Publishing online December 27, 2018) Google Scholar report that two subpopulations of macrophages expand during obesity to impair ¦Â cell function %U https://www.cell.com/immunity/fulltext/S1074-7613(18)30574-0