%0 Journal Article
%T TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics
%J -
%D 2019
%R https://doi.org/10.1016/j.molcel.2019.03.009
%X In this issue of Molecular Cell, Rodriguez-Meira et al. (2019) Rodriguez-Meira A. Buck G. Clark S.-A. Povinelli B.J. Alcolea V. Louka E. McGowan S. Hamblin A. Sousos N. Barkas N. et al. Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing. Mol. Cell. 2019; 73 ( this issue) : 1292-1305 Google Scholar present TARGET-seq, an elegant single-cell method that genotypes somatic mutations and captures whole transcriptomes in the same tumor cells, thus paving the way to directly link somatic mutations with resulting transcriptional phenotypes in clonally diverse cancer populations
%U https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30183-2