%0 Journal Article %T Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins %J - %D 2019 %R https://doi.org/10.1016/j.molcel.2018.10.019 %X £¿ Mapping of leading-strand start sites at two S. cerevisiae DNA replication origins £¿ Leading-strand synthesis is established from ¡°lagging-strand¡± primers £¿ Pol ¦Ä likely plays a key role in establishing all nascent leading strands £¿ Replisomes remain interdependent until new leading strands are establishe %U https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30879-7