%0 Journal Article %T Theoretical Chemistry Answers Bimolecular Signaling Debate in [4Fe4S] Proteins %J - %D 2019 %R https://doi.org/10.1016/j.chempr.2018.12.022 %X In this issue of Chem, Migliore and co-workers performed a theoretical study on redox signaling between the [4Fe4S] clusters in the C-terminal domain of DNA primase and polymerase ¦Á. They found that redox signaling cannot be accomplished solely via DNA-mediated charge transport, which requires [4Fe4S]-to-DNA and DNA-to-[4Fe4S] charge transfer %U https://www.cell.com/chem/fulltext/S2451-9294(18)30585-0