%0 Journal Article
%T The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions
%J -
%D 2019
%R https://doi.org/10.1016/j.chom.2019.03.009
%X Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a platform to develop improved models of pathogen-induced disease and to map polymorphic host response loci associated with variation in susceptibility to pathogens
%U https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(19)30161-1