%0 Journal Article
%T Nucleus¨CInvadopodia Duo During Cancer Invasion
%J -
%D 2019
%R https://doi.org/10.1016/j.tcb.2018.11.006
%X Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cells in dense tissues, which otherwise get trapped in the matrix because of limited nuclear deformability. A digest-on-demand response has been identified, which requires nucleus¨Cmicrotubule linkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement
%U https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30200-9