%0 Journal Article
%T Activated Extracellular Vesicles as New Therapeutic Targets?
%J -
%D 2019
%R https://doi.org/10.1016/j.tcb.2019.02.003
%X A recent study by Genschmer et al. ( Cell 2019;176:113¨C126) presents provocative new evidence that extracellular vesicles/exosomes released by activated neutrophils can degrade extracellular proteins. Elastase that is produced by neutrophils both coats the exosomes and is protected by the exosomes from inactivation by ¦Á1 antitrypsin, ultimately causing the pathological degradation of extracellular protein fibrils in lung alveoli
%U https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30025-X