%0 Journal Article
%T Metastasis Stemming from Circulating Tumor Cell Clusters
%J -
%D 2019
%R https://doi.org/10.1016/j.tcb.2019.02.001
%X Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela et al. ( Cell 2019;176:98¨C112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of ¡®stemness¡¯ in CTC clusters
%U https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(19)30023-6