%0 Journal Article %T De novo Assembly Vastly Expands the Known Microbial Universe %J - %D 2019 %R https://doi.org/10.1016/j.tim.2019.02.007 %X The study of the human microbiome relies heavily on the genomes of bacterial isolates that can be grown in culture. A recent study (Pasolli et al. Cell 2019;176:649¨C662) of stool microbiome samples generated over 150 000 microbial genomes without any culture, vastly expanding our knowledge of the biases in existing reference databases %U https://www.cell.com/trends/microbiology/fulltext/S0966-842X(19)30058-7