%0 Journal Article
%T Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2018.12.101
%X £¿ SIRT2 is required for HSC maintenance at an old but not young age £¿ SIRT2 represses the activation of the NLRP3 inflammasome in HSCs £¿ NLRP3 inflammasome is activated in aged HSCs due to increased mitochondrial stress £¿ SIRT2 activation, NLRP3 inactivation, or caspase 1 inactivation reverses HSC agin
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32076-X