%0 Journal Article
%T Epistasis in a Fitness Landscape Defined by Antibody-Antigen Binding Free Energy
%J -
%D 2019
%R https://doi.org/10.1016/j.cels.2018.12.004
%X £¿ Epistatic effects are extracted from massive measurements of binding energies £¿ Variability in binding is 62% due to additive effects and 25%¨C35% due to epistasis £¿ Up to 4% of double mutants have sign epistasis £¿ Simulations suggest that epistasis may expand paths of affinity maturatio
%U https://www.cell.com/cell-systems/fulltext/S2405-4712(18)30478-2