%0 Journal Article
%T Improving Estimates of Compensatory cis¨Ctrans Regulatory Divergence
%J -
%D 2019
%R https://doi.org/10.1016/j.tig.2018.09.003
%X Interspecific hybrids have played a key role in research on gene expression regulation. A growing number of studies have measured genome-wide allele-specific expression in hybrids and observed that cis-regulatory changes often oppose trans-acting changes affecting the same genes, suggesting stabilizing selection for compensatory changes. However, the most common method for estimating these effects is biased, producing artifactual patterns of compensatory evolution. Here I introduce a simple modification leveraging biological replicates that ameliorates the bias
%U https://www.cell.com/trends/genetics/fulltext/S0168-9525(18)30155-0