%0 Journal Article
%T Post-Translational Modification, Phase Separation, and Robust Gene Transcription
%J -
%D 2019
%R https://doi.org/10.1016/j.tig.2018.11.002
%X A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge
%U https://www.cell.com/trends/genetics/fulltext/S0168-9525(18)30198-7