%0 Journal Article
%T Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes
%J -
%D 2019
%R https://doi.org/10.1016/j.cmet.2019.02.004
%X Recent articles have highlighted the lack of reproducibility of data from scientific publications. Here we would argue that a better way to describe and also tackle this matter is to use the term ¡°lack of robustness,¡± since it points toward potential solutions. Presenting several case reports, we highlight examples with common underlying issues from Novo Nordisk¡¯s experience: animal model variability, reagent quality, and inter-lab variability. We discuss means to prevent these issues and argue for increased collaborative work and transparent manuscript revision procedures. Collectively, we believe these measures will help promote a more rapid and efficient self-corrective process in diabetes drug target research
%U https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30068-3