%0 Journal Article
%T The Structure of HPK1 Kinase Domain: To Boldly Go Where No Immuno-Oncology Drugs Have Gone Before
%J -
%D 2019
%R https://doi.org/10.1016/j.str.2018.12.009
%X In this issue of Structure, Wu et al. (2018) Wu P. Sneeringer C.J. Pitts K.E. Day E.S. Chan B.K. Wei B. Lehoux I. Mortara K. Li H. Wu J. et al. Hematopoietic progenitor kinase-1 structure in a domain-swapped dimer. Structure. 2018; 27 ( this issue) : 125-133 Google Scholar report several apo and small-molecule inhibitor-bound structures of the kinase domain of hematopoietic progenitor kinase 1, a ser/thr kinase that functions as an inhibitor of T cell activation. The studies reveal that the HPK1 kinase domain exists as a domain-swapped dimer
%U https://www.cell.com/structure/fulltext/S0969-2126(18)30465-9