%0 Journal Article %T The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1¦Á by Thrombin %J - %D 2019 %R https://doi.org/10.1016/j.immuni.2019.03.003 %X £¿ Mammalian IL-1¦Á contains a highly conserved thrombin consensus site £¿ Thrombin cleavage leads to IL-1¦Á activation and shedding from the cell surface £¿ Thrombin activates IL-1¦Á after epidermal wounding and after acute platelet loss £¿ Thrombin-cleaved IL-1¦Á is also detected in humans during sepsi %U https://www.cell.com/immunity/fulltext/S1074-7613(19)30093-7