%0 Journal Article
%T Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson¡¯s Disease Models
%J -
%D 2019
%R https://doi.org/10.1016/j.neuron.2018.12.004
%X £¿ Thalamic neurons more potently activated indirect pathway striatal neurons in PD mice £¿ This amplification was dependent upon striatal cholinergic interneurons (ChIs) £¿ ChI-activated, presynaptic nicotinic receptors increased thalamic glutamate release £¿ Suppressing this signaling pathway restored motor learning in PD mic
%U https://www.cell.com/neuron/fulltext/S0896-6273(18)31080-8