%0 Journal Article
%T Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents ¦Â Cell Death via ATG16L1 Interaction and Autophagy Regulation
%J -
%D 2019
%R https://doi.org/10.1016/j.cmet.2018.09.009
%X £¿ Islet C3 expression is upregulated in human T2D and rodent models of diabetes £¿ C3 is present within the cytosol and binds autophagy-related protein 16-1 (ATG16L1) £¿ ¦Â cells lacking C3 have impaired autophagy £¿ Intracellular C3 protects ¦Â cells from palmitic acid/IAPP-mediated apoptosi
%U https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30574-6