%0 Journal Article
%T Glutathione Metabolism: An Achilles¡¯ Heel of ARID1A-Deficient Tumors
%J -
%D 2019
%R https://doi.org/10.1016/j.ccell.2019.01.017
%X In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations
%U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30051-0