%0 Journal Article
%T Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity
%J -
%D 2019
%R https://doi.org/10.1016/j.it.2019.01.009
%X In a recent study, Zhang et al. ( Immunity 2019;50:121¨C136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-¦Â signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors
%U https://www.cell.com/trends/immunology/fulltext/S1471-4906(19)30009-2