%0 Journal Article
%T BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association
%J -
%D 2019
%R https://doi.org/10.1016/j.celrep.2019.03.040
%X £¿ BH3 binding to BAX groove essential for late but not early steps in BAX activation £¿ Mutations identified in BAX helices 1 and 6 near a proposed second BH3 binding site £¿ They reduced BH3 binding to this site and stabilized BAX in inactive conformations £¿ They revealed allosteric changes controlling BAX mitochondrial membrane associatio
%U https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30356-0