%0 Journal Article %T Orbitofrontal Cortex: A ¡®Non-rewarding¡¯ New Treatment Target in Depression? %J - %D 2019 %R https://doi.org/10.1016/j.cub.2018.11.057 %X Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies %U https://www.cell.com/current-biology/fulltext/S0960-9822(18)31556-2