%0 Journal Article %T The Origin of CIMP, At Last %J - %D 2019 %R https://doi.org/10.1016/j.ccell.2019.01.015 %X In this issue of Cancer Cell, Tao et al. provide compelling evidence that aging-like DNA methylation of multiple CpG islands, the CpG island methylator phenotype (CIMP), produces a cellular context that can tolerate BRAF activation avoiding senescence by dedicating 5-month culture of colon-derived organoids to epigenomic and stemness analysis %U https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30049-2