%0 Journal Article
%T Understanding the Conformational Dynamics of a Pentameric Ligand-Gated Ion Channel through Markov State Modeling
%J -
%D 2019
%R https://doi.org/10.1016/j.bpj.2018.11.2138
%X Pentameric ligand-gated ion channels (pLGICs) are of great importance as inter-cellular communicators that mediate electrochemical signaling in neurons and other excitable cells. PLGICs are also typical examples of membrane proteins that exhibit allosteric regulation - a process that has not yet been fully understood. The Gloeobacter violaceusligand-gated ion channel (GLIC), derived from bacteria and gated by pH , is one of the easier members of the pLGIC family to study experimentally, which has resulted in a multitude of available experimental structures covering resting, active and intermediate states - including some with mutations and modulators. Yet, studying GLIC may allow structural, dynamical or functional insights to be generalized to other pLGICs
%U https://www.cell.com/biophysj/fulltext/S0006-3495(18)33403-9