%0 Journal Article
%T The association of lecithin retinol acyltransferase and the 25(OH)D receptor with pediatric overweight and obesity
%J -
%D 2019
%R https://doi.org/10.1038/s41430-019-0422-0
%X The aim of this study is to determine whether lecithin retinol acyltransferase (LRAT) as well as biomarkers of vitamin A (VA) and vitamin D are related to indices of obesity in childhood. A total of 164 children (aged 6¨C12 years, female 49.39%), comprising 66 children in the overweight/obese group and 98 children in the lean group, were included. LRAT expression was remarkably lower in the overweight/obese group than in the lean group (P£¿<£¿0.01). Compared with the lean group, the overweight/obese group had elevated VA (0.95£¿¡À£¿0.25 vs. 0.83£¿¡À£¿0.21£¿¦Ìmol/L, P£¿<£¿0.01). Moreover, the levels of 25(OH)D (25-hydroxyvitamin D) and its receptor were lower in overweight/obese subjects than in lean subjects (P£¿=£¿0.06 and <0.05). LRAT was negatively correlated with body mass index and waist circumference (R£¿=£¿£¿0.27, P£¿<£¿0.01, and R£¿=£¿£¿0.18, P£¿<£¿0.05, respectively) and positively correlated with high-density lipoprotein (R£¿=£¿0.18, P£¿<£¿0.05). VA metabolism may be disordered in obese children, although children with obesity have higher VA levels than lean children
%U https://www.nature.com/articles/s41430-019-0422-0