%0 Journal Article
%T YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating ¦Â-catenin signaling
%J -
%D 2018
%R https://doi.org/10.1038/s41413-018-0018-7
%X YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP¡¯s function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis. YAP is selectively expressed in osteoblast (OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with ¦Â-catenin and is necessary for maintenance of nuclear ¦Â-catenin level and Wnt/¦Â-catenin signaling. Expression of ¦Â-catenin in YAP-deficient BMSCs (bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-¦Â-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis
%U https://www.nature.com/articles/s41413-018-0018-7