%0 Journal Article
%T Re(I)-catalyzed hydropropargylation of enamides: a useful method for the preparation of 4-pentynylamine derivatives
%J -
%D 2019
%R https://doi.org/10.1038/s41429-019-0162-3
%X Hydropropargylation of enamides was achieved in good yields through the 1,4-addition of enamides to the ¦Á,¦Â-unsaturated carbene complex intermediate, followed by intramolecular hydrogen transfer to the iminium carbon. This method is useful for the synthesis of 4-pentynylamine derivatives from enamides and easily available propargyl ether. Moreover, tandem cyclization reaction was achieved to afford a pyrrolidine derivative in a single operation by using a secondary enamide
%U https://www.nature.com/articles/s41429-019-0162-3