%0 Journal Article
%T Step-economy synthesis of ¦Â-steryl sialosides using a sialyl iodide donor
%J -
%D 2019
%R https://doi.org/10.1038/s41429-019-0165-0
%X Steryl glycosides are prevalent in nature and have unique biological activities dictated by sterol structure, sugar composition, and the stereochemical attachment of the aglycone. A single configurational switch can have profound biological consequences meriting the systematic study of structure and function relationships. Steryl congeners of N-acetyl neuraminic acid (NANA) impact neurobiological processes and may also mediate host/microbe interactions. In order to study these processes, a platform for the synthesis of ¦Â-steryl sialosides has been established. Promoter-free glycosidations using a novel ¦Á-linked sialyl iodide donor efficiently provide unique amphiphilic sialoglycoconjugates for examining bioactivities in various systems
%U https://www.nature.com/articles/s41429-019-0165-0