%0 Journal Article
%T Versatile and robust C每C activation by chelation-assisted manganese catalysis
%J -
%D 2018
%R https://doi.org/10.1038/s41929-018-0187-1
%X C每H activation has been recognized as an increasingly viable tool in molecular sciences, but organometallic C每C activation is scarce, and limited to precious and toxic metal catalysts. Herein, we disclose versatile C每C activations by a robust base-metal catalyst in water. Thus, an inexpensive manganese(i) catalyst enabled C每C functionalizations with excellent levels of chemo- and position-selectivities, setting the stage for versatile C每C allylations, C每C alkenylations and C每C alkylations in water. The manganese(i) catalyst outperformed commonly used copper, iron, palladium, rhodium and ruthenium complexes, and the C每C activations occurred on steroid and amino acid motifs. Detailed kinetic and computational studies provided strong support for a kinetically relevant C每C manganesation
%U https://www.nature.com/articles/s41929-018-0187-1