%0 Journal Article
%T Formal syntheses of (£¿)-isoretronecanol, (+)-laburnine, and a concise enantioselective synthesis of (+)-turneforcidine
%J -
%D 2019
%R https://doi.org/10.1038/s41429-019-0169-9
%X The synthesis of functionalized pyroglutamates 15 and 16 could be achieved by the application of recently developed diastereodivergent asymmetric Michael addition reaction of iminoglycinate 7 to ethyl ¦Ã-silyloxycrotonate with >98:<2 diastereoselectivity followed by hydrolysis and lactamization. Formal syntheses of (£¿)-isoretronecanol and (+)-laburnine as well as a concise enantioselective synthesis of (+)-turneforcidine could be achieved from functionalized pyroglutamates 15 or 16
%U https://www.nature.com/articles/s41429-019-0169-9