%0 Journal Article
%T MCC950 closes the active conformation of NLRP3 to an inactive state
%J -
%D 2019
%R https://doi.org/10.1038/s41589-019-0278-6
%X NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is an innate immune sensor that contributes to the development of different diseases, including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer¡¯s disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibitor with potential clinical utility. However, the mechanism of action of MCC950 remains unknown. Here, we characterize the mechanism of action of MCC950 in both wild-type and autoinflammatory-related NLRP3 mutants, and demonstrate that MCC950 closes the ¡®open¡¯ conformation of active NLRP3
%U https://www.nature.com/articles/s41589-019-0278-6